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CRISPR-Based SARS-CoV-2 Saliva Test

Wainamics was chosen for this Innovative Genomics Institute project in Jennifer Doudna’s lab at UC Berkeley to provide expertise in microfluidic cartridge design and system architecture for a point-of-care saliva-based test combining isothermal amplification and a CAS-13 assay for high sensitivity, rapid testing for SARS-CoV-2.

Schematic of sample processing with CRISPR and LAMP

We optimized the cartridge design for multiplexing, enabling test results in less than 50 minutes, with 94% sensitivity and 100% specificity when validated against quantitative PCR.

Image of cartridge designs for CRISPR and LAMP assay
Cover of Nature Biomedical Engineering
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